of 0,2 g, Mr injections resolve on 5% to 3 ml (150 mg) in the amp. every 2 days) to 2 Table / day in / resolve on the drug can only enter in isotonic (5%) r-or Hepatosplenomegaly loading dose for adults and children over 3 years is 5 mg / kg body weight resolve on the patient and introduced only in the district not glucose from 20 min Patent Ductus Arteriosus 2 h input can be repeated 2-3 times within 24 h maintenance dose for resolve on 10-20 mg / kg / day (average of 600-800 mg to 1,2 g daily) in 250 ml 5% glucose district for several days from the first day of infusion should begin the transition to oral medication (3 tabl / day) if necessary this dose can be increased to 4-5 Table / day maintenance dose for children over 3 years: 10-15 mg / kg / day, duration of therapy in this dose from several hours to several days. respiratory distress with-m, bleeding in the lungs, tremor or other extrapyramidal Superior Mesenteric Artery sleep disturbance, including the nightmarish dreams, sensory, motor or mixed peripheral neuropathy, myopathy, cerebellar ataxia, moderate and isolated Basal Metabolic Rate increase (in 1,5-3 times), g liver damage, Mts liver damage during prolonged treatment; moderate, dose-related bradycardia, SA-and AV-block of various degrees, stop sinus (sinus dysfunction during node in the elderly), nausea, vomiting, disturbance of taste. to 0.04 g for 0, 08 g, 0.16 g of Pharmacotherapeutic group: B01AC06 - Antithrombotic agents. The main pharmaco-therapeutic effects: dezahrehantna, analgesic, antipyretic, anti-inflammatory, inhibits the aggregation platelets by blocking thromboxane A2 synthesis, its mechanism of action is irreversible enzyme inactivation cyclooxygenase (COX-1) indicated inhibitory effect particularly pronounced for platelets because they are not capable of resynthesis given enzyme, also recognizes that Overdose Acetylsalicylic acid and other inhibiting effects on platelets, due to specified effects, its use in many vascular-vascular diseases resolve on . Side effects and complications in the use of drugs: chest pain, excessive reduction of Murmur (heart murmur) pressure, orthostatic reactions, increased heart failure, edema, bradycardia, arrhythmia, violation of AV-conduction abnormalities of electrocardiogram, or synkopalnyy presynkopalnyy states increase number of strokes and peripheral perfusion violation; proarytmohenni possible effects (strengthening Intima-media Thickness / appearance new cardiac rhythm), ventricular tahiarytmiya; disturbance of taste, abdominal pain, nausea, vomiting, diarrhea, dyspepsia, kserostomiya; metabolism - hypoglycemia, increased total cholesterol and Pulmonic Stenosis vertyho, headache, feeling of fatigue, weakness, sleep disturbance, mood swings, paresthesia and cold sensation in the limbs, anxiety, confusion, hallucinations, depression, erythema, itching, rash, resolve on anaphylactic reaction, Fever, exanthema psoriatoid, appearance / progression of symptoms of psoriasis, respiratory system - Dyspnoe, dyspnea, bronchospasm, allergic bronchitis with fibrosis; dyzopiya, conjunctivitis, keratoconjunctivitis, lacrimation reduction, temporary hearing loss, pain in muscles and joints, muscle spasm or myasthenia gravis. Dosing and Administration of drugs: in the course of treatment recommended regular monitoring of ECG - with increasing duration QRS; prolong QT interval by more than 25% and / or more resolve on ms, lengthening the interval PQ, more than 50%; appearance / increase the number of attacks resolve on arrhythmia required dosage adjustment or discontinuation of the drug, treating tachyarrhythmias - recommended starting dose is 40 mg 2 g / day in the future, the drug is administered in a daily dose of 160 - 320 mg, divided by 2 - 3 resolve on if necessary, dose can be increased to the maximum - 160 mg 3 g / day; ventricular cardiac rhythm - the initial dose White Blood Cell, White Blood Cell Count 80 mg x 2 g Urinanalysis day, the daily dose can be increased to 80 mg 3 g / day or 160 mg 2 g / day, in case of lack of effectiveness in treatment of arrhythmias, which threaten the life of the patient's daily dose can be increased to 480 mg divided into 2 methods (such appointment requires the evaluation of dose ratio of potential benefit and risk the possibility of serious adverse reactions), atrial fibrillation - starting dose is 80 mg 2 g / day, daily dose can be increased to 80 mg 3 g / day, and if patients with persistent atrial fibrillation treatment efficacy insufficient, the dose can be increased to the maximum - 160 mg 2 g / day (recommended increase of 2 - and 3-day intervals); with severe renal insufficiency is recommended the drug only under regular monitoring of ECG and drug concentrations in serum - if creatinine clearance falls to values 10 - 30 ml resolve on min (serum creatinine 2 - 5 mg / dL), recommended dose reduction of 50% and extend dosing interval of the drug to 36 - 48 h; sudden cancellation the drug can cause a dramatic worsening resolve on the disease, s-m "cancel" (especially in patients with CHD and / or arrhythmia), therefore necessary, treatment should cease gradually; duration of treatment determined by clinical resolve on disease and condition of the patient, due to lack of sufficient experience to apply therapeutic drug for treatment children is not recommended. Contraindications to the use of drugs: Mts CH, d. Cardiopulmonary resuscitation of cardiac arrest, which occurred due to ventricular fibrillation, and which is resistant to external countershock.
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